Diabetes-causing gene can be regulated like a rheostat

Researchers have discovered a way to control a gene that causes diabetes.

HNF1A is a gene that plays a role in the development of the pancreas.

A mutation in the gene HNF1A causes a protein to not work properly, which in turn causes the beta cells to not produce insulin properly. This results in individuals developing a disease known as maturity-onset diabetes of the young,

Researchers have discovered a new role for a region of the genome near HNF1A. This region is responsible for turning off the gene.

The HNF1A gene regulates the amount of insulin produced by the pancreas. If it's working too hard, it will reduce the amount of insulin produced.

The researchers believe that many lncRNAs have a similar function to HASTER. This could lead to a better understanding of the role of lncRNAs in human disease.

The research shows that the deletion of HASTER is comparable to the deletion of HNF1A. A new study shows that non-protein coding sequences in a genome may be useful in treating disease.

The human genome has more space devoted to regulating genes than it does to the genes. In this study, we have verified one region's function. It's likely that this is the start of a bigger story.

The man is called "Ferrer." Although noncoding RNAs were initially considered to be degradation products of RNA turnover and metabolism and were often neglected, increasing evidence has demonstrated their regulatory and functional roles in diverse cellular compartments and macromolecular structures.

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