 {"id":3230,"date":"2022-11-19T12:24:34","date_gmt":"2022-11-19T07:24:34","guid":{"rendered":"https:\/\/themasterchemistry.com\/?post_type=web-story&#038;p=3230"},"modified":"2022-11-19T12:24:34","modified_gmt":"2022-11-19T07:24:34","slug":"problem-of-functionalizing-pyridines-in-the-meta-position-has-been-solved","status":"publish","type":"web-story","link":"https:\/\/themasterchemistry.com\/web-stories\/problem-of-functionalizing-pyridines-in-the-meta-position-has-been-solved\/","title":{"rendered":"Problem of Functionalizing Pyridines in the Meta-position has been solved"},"content":{"rendered":"<p><html amp=\"\" lang=\"en\"><head><meta charSet=\"utf-8\"\/><meta name=\"viewport\" content=\"width=device-width,minimum-scale=1,initial-scale=1\"\/><script async=\"\" src=\"https:\/\/cdn.ampproject.org\/v0.js\"><\/script><script async=\"\" src=\"https:\/\/cdn.ampproject.org\/v0\/amp-story-1.0.js\" custom-element=\"amp-story\"><\/script><link 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  padding: 6px 12px;\n                vertical-align: middle;\n                border-radius: 15px;\n                background: rgba(11, 11, 11, 0.6);\n                color: rgba(255, 255, 255, 1);\n                font-family: -apple-system, BlinkMacSystemFont, \"Segoe UI\", Roboto, Oxygen-Sans, Ubuntu, Cantarell, \"Helvetica Neue\", sans-serif;;\n                font-size: calc(4 * var(--story-page-vw));\n                line-height: 1.4;\n                word-break: break-word;\n                word-wrap: break-word;\n                overflow-wrap: break-word;\n              }\n              <\/style>\n<p><meta name=\"web-stories-replace-head-start\"\/><title>Problem of Functionalizing Pyridines in the Meta-position has been solved<\/title><link rel=\"canonical\" href=\"https:\/\/themasterchemistry.com\/?post_type=web-story&amp;p=3230\"\/><meta name=\"web-stories-replace-head-end\"\/><\/head><body><amp-story standalone=\"\" publisher=\"Master Chemistry\" publisher-logo-src=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2021\/05\/favicon.png\" title=\"Problem of Functionalizing Pyridines in the Meta-position has been solved\" poster-portrait-src=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/cropped-dioxin-g168c484e8_640.png\" background-audio=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/Acoustic.mp3\"><amp-story-page id=\"fb9e9e6b-998e-430b-b965-eaf3f3d0c1f8\" auto-advance-after=\"20s\"><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\" style=\"background-color:#2e2e31\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:0;top:-9.25926%;width:100%;height:118.51852%;opacity:1\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-2abc7543-8c65-4b02-8fde-6c5e72d950fd\">\n<div style=\"position:absolute;width:278.69281%;height:100%;left:-89.34641%;top:0%\" data-leaf-element=\"true\"><amp-img layout=\"fill\" src=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-85.png\" alt=\"image\" srcSet=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-85.png 533w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-85-300x191.png 300w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-85-150x96.png 150w\" sizes=\"(min-width: 1024px) 126vh, 279vw\" disable-inline-width=\"true\"><\/amp-img><\/div>\n<div class=\"element-overlay-area\" style=\"background-color:rgba(0,0,0,0.5)\"><\/div>\n<\/div>\n<\/div>\n<div class=\"page-background-overlay-area\" style=\"background-color:rgba(0,0,0,0.5)\"><\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:11.40777%;top:23.6246%;width:76.69903%;height:52.10356%;opacity:1\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.6329113924050633% 0.6329113924050633% 0.6329113924050633% 0.6329113924050633% \/ 0.6211180124223602% 0.6211180124223602% 0.6211180124223602% 0.6211180124223602%\" id=\"el-a3dc8a74-b02c-44ee-9210-85efdee78dda\">\n<h1 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.1290545886075945% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.728155em;line-height:1.19;text-align:left;padding:0;color:#000000\"><span><span style=\"font-weight: 700; color: #fff\">Problem of Functionalizing Pyridines in the Meta-position has been solved<\/span><\/span><\/h1>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><\/amp-story-page><amp-story-page id=\"45dd9b07-a719-44fa-bbe2-685d0e8d913f\" auto-advance-after=\"20s\"><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-f1b5cd34-a536-4c27-86e5-0de6b7ee7586\",\"keyframes\":[{\"offset\":0,\"transform\":\"translate3d(0, -167.25147%, 0)\",\"easing\":\"cubic-bezier(.5, 0, 1, 1)\"},{\"offset\":0.29,\"transform\":\"translate3d(0, 0%, 0)\",\"easing\":\"cubic-bezier(0, 0, .5, 1)\"},{\"offset\":0.45,\"transform\":\"translate3d(0, -47.03111336400001%, 0)\",\"easing\":\"cubic-bezier(.5, 0, 1, 1)\"},{\"offset\":0.61,\"transform\":\"translate3d(0, 0%, 0)\",\"easing\":\"cubic-bezier(0, 0, .5, 1)\"},{\"offset\":0.71,\"transform\":\"translate3d(0, -15.989240532000002%, 0)\",\"easing\":\"cubic-bezier(.5, 0, 1, 1)\"},{\"offset\":0.8,\"transform\":\"translate3d(0, 0%, 0)\",\"easing\":\"cubic-bezier(0, 0, .5, 1)\"},{\"offset\":0.85,\"transform\":\"translate3d(0, -6.004327773000001%, 0)\",\"easing\":\"cubic-bezier(.5, 0, 1, 1)\"},{\"offset\":0.92,\"transform\":\"translate3d(0, 0%, 0)\",\"easing\":\"cubic-bezier(0, 0, .5, 1)\"},{\"offset\":0.96,\"transform\":\"translate3d(0, -2.609122932%, 0)\",\"easing\":\"cubic-bezier(.5, 0, 1, 1)\"},{\"offset\":1,\"transform\":\"translate3d(0, 0%, 0)\",\"easing\":\"cubic-bezier(0, 0, .5, 1)\"}],\"delay\":0,\"duration\":1600,\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-9f43fb5c-e5bf-44f3-8b3e-3b9908c02af5\",\"keyframes\":{\"opacity\":[0,1]},\"delay\":0,\"duration\":600,\"easing\":\"cubic-bezier(0.4, 0.4, 0.0, 1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\" style=\"background-color:#fff\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:0;top:-9.25926%;width:100%;height:118.51852%;opacity:1\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-06176914-a5cb-44c9-a5ee-a84e2350b52b\">\n<div class=\"fill\" style=\"will-change:transform\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:15.53398%;top:10.19417%;width:69.90291%;height:52.26537%;opacity:1\">\n<div id=\"anim-f1b5cd34-a536-4c27-86e5-0de6b7ee7586\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(0, -167.25147%, 0)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.6944444444444444% 0.6944444444444444% 0.6944444444444444% 0.6944444444444444% \/ 0.6191950464396285% 0.6191950464396285% 0.6191950464396285% 0.6191950464396285%\" id=\"el-d00ed9e0-9c94-4de2-9052-8ee165e8f2c2\">\n<h2 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.146484375% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.485437em;line-height:1.2;text-align:left;padding:0;color:#000000\"><span>One of the most efficient ways to synthesize a diverse range of bioactive compounds involves the direct functionalization of the C-H bonds of pyridines<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"position:absolute;pointer-events:none;left:14.80583%;top:68.4466%;width:70.87379%;height:26.05178%;opacity:1\">\n<div id=\"anim-9f43fb5c-e5bf-44f3-8b3e-3b9908c02af5\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:none\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-58cda674-9b6f-49f2-922f-b26deebd4590\">\n<div style=\"position:absolute;width:100%;height:115.69343%;left:0%;top:-7.84672%\" data-leaf-element=\"true\"><amp-img layout=\"fill\" src=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-85.png\" alt=\"image\" srcSet=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-85.png 533w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-85-300x191.png 300w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-85-150x96.png 150w\" sizes=\"(min-width: 1024px) 32vh, 71vw\" disable-inline-width=\"true\"><\/amp-img><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><\/amp-story-page><amp-story-page id=\"58da89dd-311d-484d-b740-8ac6938b0ffb\" auto-advance-after=\"20s\"><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-3f6ed940-d2ec-4ffe-8d43-b00111a9dd72\",\"keyframes\":{\"opacity\":[0,1]},\"delay\":0,\"duration\":600,\"easing\":\"cubic-bezier(0.2, 0.6, 0.0, 1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-cb3a3b45-0217-4cee-b35d-4a47dfb3c7e1\",\"keyframes\":{\"transform\":[\"translate3d(-123.02158%, 0px, 0)\",\"translate3d(0px, 0px, 0)\"]},\"delay\":0,\"duration\":600,\"easing\":\"cubic-bezier(0.2, 0.6, 0.0, 1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-88f6eb48-1595-4193-b32f-d4f900c597a1\",\"keyframes\":{\"opacity\":[0,1]},\"delay\":0,\"duration\":600,\"easing\":\"cubic-bezier(0.2, 0.6, 0.0, 1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-2917a0c1-8729-4a04-ab15-334d7041a09a\",\"keyframes\":{\"transform\":[\"translate3d(0px, -275.50091%, 0)\",\"translate3d(0px, 0px, 0)\"]},\"delay\":0,\"duration\":600,\"easing\":\"cubic-bezier(0.2, 0.6, 0.0, 1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\" style=\"background-color:#fff\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:0;top:-9.25926%;width:100%;height:118.51852%;opacity:1\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-3ae6923f-deb1-458b-b108-9fd15727db7c\">\n<div class=\"fill\" style=\"will-change:transform\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:15.53398%;top:10.19417%;width:67.47573%;height:46.44013%;opacity:1\">\n<div id=\"anim-3f6ed940-d2ec-4ffe-8d43-b00111a9dd72\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:none\">\n<div id=\"anim-cb3a3b45-0217-4cee-b35d-4a47dfb3c7e1\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(-123.02158%, 0px, 0)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.7194244604316548% 0.7194244604316548% 0.7194244604316548% 0.7194244604316548% \/ 0.6968641114982579% 0.6968641114982579% 0.6968641114982579% 0.6968641114982579%\" id=\"el-a5d44d57-65cb-4e89-91aa-cf571a06889f\">\n<h2 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.15175359712230216% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.485437em;line-height:1.2;text-align:left;padding:0;color:#000000\"><span>This is a straightforward approach to synthesizing complex molecules, including in the final stage of the synthesis sequence<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div 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id=\"anim-bfb1d9ba-ac6f-4c61-b434-deab78602ec5\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:none\">\n<div id=\"anim-981a8267-5fb2-4cf7-aee2-739e58ab3961\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(0px, 256.26382%, 0)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.6688963210702341% 0.6688963210702341% 0.6688963210702341% 0.6688963210702341% \/ 0.796812749003984% 0.796812749003984% 0.796812749003984% 0.796812749003984%\" id=\"el-bafdfc99-183a-4077-825e-225a7be2efe2\">\n<h2 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.1410953177257525% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.485437em;line-height:1.2;text-align:left;padding:0;color:#000000\"><span>The problem is that the pyridine in a certain position in relation to the nitrogen atom is extremely challenging and rare<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"position:absolute;pointer-events:none;left:11.65049%;top:49.51456%;width:74.27184%;height:50%;opacity:1\">\n<div id=\"anim-bf1c33e5-7e32-44e1-9d80-a223be449fb7\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:none\">\n<div id=\"anim-2f15aa96-d558-48ed-a71f-97f05f05ce20\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(118.95425%, 0px, 0)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-64863fac-3115-4543-90f9-ab3b7fa5059f\">\n<div style=\"position:absolute;width:134.64053%;height:100%;left:-17.32027%;top:0%\" data-leaf-element=\"true\"><amp-img layout=\"fill\" src=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-87.png\" alt=\"image\" srcSet=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-87.png 500w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-87-300x225.png 300w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-87-150x113.png 150w\" sizes=\"(min-width: 1024px) 33vh, 74vw\" disable-inline-width=\"true\"><\/amp-img><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><\/amp-story-page><amp-story-page id=\"22118efc-2556-4ccf-9686-5e396fce0aeb\" auto-advance-after=\"20s\"><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script 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style=\"background-color:#fff\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:0;top:-9.25926%;width:100%;height:118.51852%;opacity:1\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-69bf440c-0bc4-43c9-b7de-6ee9651bd26a\">\n<div class=\"fill\" style=\"will-change:transform\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:16.01942%;top:1.2945%;width:67.47573%;height:63.91586%;opacity:1\">\n<div id=\"anim-d9b21593-b9c0-4705-9165-d1d4abfb39a5\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:scale(1)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.7194244604316548% 0.7194244604316548% 0.7194244604316548% 0.7194244604316548% \/ 0.5063291139240507% 0.5063291139240507% 0.5063291139240507% 0.5063291139240507%\" id=\"el-285a66b7-4486-4db2-9fea-18a6f9577865\">\n<h2 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.15175359712230216% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.485437em;line-height:1.2;text-align:left;padding:0;color:#000000\"><span>A team of researchers led by Prof. Armido Studer at the Institute of Organic Chemistry at the University of M\u00fcnster has developed a new strategy on various functions of<span style=\"font-weight: 700\"> <\/span>meta-position<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"position:absolute;pointer-events:none;left:12.13592%;top:65.69579%;width:75.72816%;height:33.81877%;opacity:1\">\n<div id=\"anim-c8c1dd34-37ac-4d12-91a0-b63af14ad77f\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:rotate(-540deg) scale(0.1)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-93f4babf-ad2c-4a71-9628-bbe637a4c7ae\">\n<div style=\"position:absolute;width:100%;height:149.28231%;left:0%;top:-24.64115%\" data-leaf-element=\"true\"><amp-img layout=\"fill\" src=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-88.png\" alt=\"image\" srcSet=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-88.png 500w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-88-300x300.png 300w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-88-150x150.png 150w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-88-96x96.png 96w\" sizes=\"(min-width: 1024px) 34vh, 76vw\" disable-inline-width=\"true\"><\/amp-img><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><\/amp-story-page><amp-story-page id=\"b997f979-8b9a-47e0-a8a2-0776d1a0a944\" auto-advance-after=\"20s\"><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-4a9c95a7-4042-4727-abc5-d172a25246f7\",\"keyframes\":{\"transform\":[\"translate3d(-123.74101%, 0px, 0)\",\"translate3d(0px, 0px, 0)\"]},\"delay\":0,\"duration\":1000,\"easing\":\"cubic-bezier(.2, 0, .8, 1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script 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1)\",\"fill\":\"forwards\"}]<\/script><\/amp-story-animation><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\" style=\"background-color:#fff\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:0;top:-9.25926%;width:100%;height:118.51852%;opacity:1\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-e2c6bb80-878e-49a6-98f6-492c4343446c\">\n<div class=\"fill\" style=\"will-change:transform\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:16.01942%;top:8.89968%;width:67.47573%;height:28.9644%;opacity:1\">\n<div id=\"anim-4a9c95a7-4042-4727-abc5-d172a25246f7\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(-123.74101%, 0px, 0)\">\n<div id=\"anim-db64413b-3933-4ee1-ac92-2411f94f89d0\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:rotateZ(-180deg)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.7194244604316548% 0.7194244604316548% 0.7194244604316548% 0.7194244604316548% \/ 1.1173184357541899% 1.1173184357541899% 1.1173184357541899% 1.1173184357541899%\" id=\"el-e6e022c9-e362-4859-94f2-cea0eba3c7f7\">\n<h2 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.15175359712230216% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.485437em;line-height:1.2;text-align:left;padding:0;color:#000000\"><span>it was various functional groups into the meta-position of pYRidines.<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"position:absolute;pointer-events:none;left:11.65049%;top:49.83819%;width:76.69903%;height:37.70227%;opacity:1\">\n<div id=\"anim-06adc90c-b755-4032-9090-adfac74da9e1\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(115.18987%, 0px, 0)\">\n<div id=\"anim-4cdc15e3-42f0-43a4-b90b-748d53d053e2\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:rotateZ(180deg)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" 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class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:0;top:-9.25926%;width:100%;height:118.51852%;opacity:1\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-3fa1401e-44bb-4bd9-9868-5472a2f90547\">\n<div class=\"fill\" style=\"will-change:transform\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:16.01942%;top:11.8123%;width:72.57282%;height:11.48867%;opacity:1\">\n<div id=\"anim-2776486c-5c37-4953-98ac-733bb9a8efc5\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(-122.07358%, 0px, 0)\">\n<div id=\"anim-470b7fa5-a2f3-41be-96cc-bf70c38ea5cb\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:none\">\n<div id=\"anim-26eb3e5e-d9c9-4f4e-ba35-10f6297f1762\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:scale(0.15)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.6688963210702341% 0.6688963210702341% 0.6688963210702341% 0.6688963210702341% \/ 2.8169014084507045% 2.8169014084507045% 2.8169014084507045% 2.8169014084507045%\" id=\"el-50478a84-a9b7-48f9-ab22-b7681dda9d14\">\n<h2 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.1410953177257525% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.485437em;line-height:1.2;text-align:left;padding:0;color:#000000\"><span>Their study is now available in Science<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"position:absolute;pointer-events:none;left:16.01942%;top:37.54045%;width:72.57282%;height:54.36893%;opacity:1\">\n<div id=\"anim-a51d94d2-3f16-43a0-8537-7074aa95be29\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(115.71905%, 0px, 0)\">\n<div id=\"anim-8044da4a-b13a-4a33-bf35-477c3c33bf1a\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:rotateZ(180deg)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-0130a458-0c30-4a4f-82bf-011037569c98\">\n<div style=\"position:absolute;width:168.73059%;height:100%;left:-34.36529%;top:0%\" data-leaf-element=\"true\"><amp-img layout=\"fill\" src=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-89.png\" alt=\"image\" srcSet=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-89.png 500w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-89-300x200.png 300w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-89-150x100.png 150w\" sizes=\"(min-width: 1024px) 33vh, 73vw\" disable-inline-width=\"true\"><\/amp-img><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><\/amp-story-page><amp-story-page id=\"d9081c2b-db6b-41f3-b3e2-431abb5b8cdb\" auto-advance-after=\"20s\"><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-28b0dcb5-8d9c-46cc-bf2b-c9e8c64bbbec\",\"keyframes\":{\"opacity\":[0,1]},\"delay\":0,\"duration\":2000,\"easing\":\"cubic-bezier(.3,0,.55,1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-72c79a62-b864-4483-91a3-36a2d39f466f\",\"keyframes\":{\"transform\":[\"scale(0.3333333333333333)\",\"scale(1)\"]},\"delay\":0,\"duration\":2000,\"easing\":\"cubic-bezier(.3,0,.55,1)\",\"fill\":\"forwards\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-e1f6786a-8ad5-4ac4-9ba3-9ec89776f1e2\",\"keyframes\":{\"opacity\":[1,1]},\"delay\":0,\"duration\":2000,\"easing\":\"cubic-bezier(.3,0,.55,1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-71edeff3-438b-4478-8f9a-c0350cc8ad5f\",\"keyframes\":{\"transform\":[\"scale(3)\",\"scale(1)\"]},\"delay\":0,\"duration\":2000,\"easing\":\"cubic-bezier(.3,0,.55,1)\",\"fill\":\"forwards\"}]<\/script><\/amp-story-animation><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\" style=\"background-color:#fff\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:0;top:-9.25926%;width:100%;height:118.51852%;opacity:1\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-1d96b921-4a66-4721-8117-42ba3b584825\">\n<div class=\"fill\" style=\"will-change:transform\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:16.01942%;top:11.8123%;width:72.57282%;height:46.60194%;opacity:1\">\n<div id=\"anim-28b0dcb5-8d9c-46cc-bf2b-c9e8c64bbbec\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:none\">\n<div id=\"anim-72c79a62-b864-4483-91a3-36a2d39f466f\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:scale(0.3333333333333333)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.6688963210702341% 0.6688963210702341% 0.6688963210702341% 0.6688963210702341% \/ 0.6944444444444444% 0.6944444444444444% 0.6944444444444444% 0.6944444444444444%\" id=\"el-7fa0772d-cb3f-462d-8769-f561b5183f49\">\n<h2 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.1410953177257525% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.485437em;line-height:1.2;text-align:left;padding:0;color:#000000\"><span>In addition, the researchers developed processes that can transform drugs into compounds with trifluoromethyl and chlorine substituents<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"position:absolute;pointer-events:none;left:16.01942%;top:62.62136%;width:68.4466%;height:36.73139%;opacity:1\">\n<div id=\"anim-e1f6786a-8ad5-4ac4-9ba3-9ec89776f1e2\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:none\">\n<div id=\"anim-71edeff3-438b-4478-8f9a-c0350cc8ad5f\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:scale(3)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-5a61a389-dc19-40db-bee7-8d6b18235651\">\n<div style=\"position:absolute;width:113.64205%;height:100%;left:-6.82103%;top:0%\" data-leaf-element=\"true\"><amp-img layout=\"fill\" src=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-90.png\" alt=\"image\" srcSet=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-90.png 480w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-90-300x213.png 300w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-90-150x106.png 150w\" sizes=\"(min-width: 1024px) 31vh, 68vw\" disable-inline-width=\"true\"><\/amp-img><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><\/amp-story-page><amp-story-page id=\"5b8e0100-0715-41b9-ad86-b5ddb9c402f8\" auto-advance-after=\"20s\"><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-02caf785-d04c-45ca-9ce1-f21112c04ab8\",\"keyframes\":[{\"offset\":0,\"transform\":\"translate3d(0, -251.90366%, 0)\",\"easing\":\"cubic-bezier(.5, 0, 1, 1)\"},{\"offset\":0.29,\"transform\":\"translate3d(0, 0%, 0)\",\"easing\":\"cubic-bezier(0, 0, .5, 1)\"},{\"offset\":0.45,\"transform\":\"translate3d(0, -70.835309192%, 0)\",\"easing\":\"cubic-bezier(.5, 0, 1, 1)\"},{\"offset\":0.61,\"transform\":\"translate3d(0, 0%, 0)\",\"easing\":\"cubic-bezier(0, 0, .5, 1)\"},{\"offset\":0.71,\"transform\":\"translate3d(0, -24.081989896%, 0)\",\"easing\":\"cubic-bezier(.5, 0, 1, 1)\"},{\"offset\":0.8,\"transform\":\"translate3d(0, 0%, 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style=\"background-color:#fff\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:0;top:-9.25926%;width:100%;height:118.51852%;opacity:1\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-3fe31302-499d-465f-9198-bb5ae72de92b\">\n<div class=\"fill\" style=\"will-change:transform\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:16.01942%;top:11.8123%;width:72.57282%;height:23.13916%;opacity:1\">\n<div id=\"anim-02caf785-d04c-45ca-9ce1-f21112c04ab8\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(0, -251.90366%, 0)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.6688963210702341% 0.6688963210702341% 0.6688963210702341% 0.6688963210702341% \/ 1.3986013986013985% 1.3986013986013985% 1.3986013986013985% 1.3986013986013985%\" id=\"el-0a9bbd5b-9d77-4b67-b167-045b2572dd78\">\n<h2 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.1410953177257525% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.485437em;line-height:1.2;text-align:left;padding:0;color:#000000\"><span>it was used relatively little effort and taking place in one single reaction vessel.<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"position:absolute;pointer-events:none;left:15.53398%;top:44.49838%;width:65.7767%;height:55.01618%;opacity:1\">\n<div id=\"anim-a4b4fe60-7836-4fb9-af5e-1cb61aa18016\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:none\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-12522af6-2867-4d82-a06f-893cacbbdac5\">\n<div style=\"position:absolute;width:107.74907%;height:100%;left:-3.87454%;top:0%\" data-leaf-element=\"true\"><amp-img layout=\"fill\" src=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-91.png\" alt=\"image\" srcSet=\"https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-91.png 292w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-91-258x300.png 258w,https:\/\/themasterchemistry.com\/wp-content\/uploads\/2022\/11\/image-91-150x175.png 150w\" sizes=\"(min-width: 1024px) 30vh, 66vw\" disable-inline-width=\"true\"><\/amp-img><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><\/amp-story-page><amp-story-page id=\"e8ce5c9f-680e-4e4a-a5e8-b30fdfde7af5\" auto-advance-after=\"20s\"><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-c24343bd-8743-4343-b62a-a82ab34f21b1\",\"keyframes\":{\"opacity\":[0,1]},\"delay\":0,\"duration\":600,\"easing\":\"cubic-bezier(0.2, 0.6, 0.0, 1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" trigger=\"visibility\"><script type=\"application\/json\">[{\"selector\":\"#anim-112bde06-aec6-46b2-9e93-ec5828e18655\",\"keyframes\":{\"transform\":[\"translate3d(-122.07358%, 0px, 0)\",\"translate3d(0px, 0px, 0)\"]},\"delay\":0,\"duration\":600,\"easing\":\"cubic-bezier(0.2, 0.6, 0.0, 1)\",\"fill\":\"both\"}]<\/script><\/amp-story-animation><amp-story-animation layout=\"nodisplay\" 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style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-04dbe1f1-61ed-4f5a-b773-2afa865b906b\">\n<div class=\"fill\" style=\"will-change:transform\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/amp-story-grid-layer><amp-story-grid-layer template=\"vertical\" aspect-ratio=\"412:618\" class=\"grid-layer\"><\/p>\n<div class=\"page-fullbleed-area\">\n<div class=\"page-safe-area\">\n<div style=\"position:absolute;pointer-events:none;left:16.01942%;top:3.39806%;width:72.57282%;height:52.10356%;opacity:1\">\n<div id=\"anim-c24343bd-8743-4343-b62a-a82ab34f21b1\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:none\">\n<div id=\"anim-112bde06-aec6-46b2-9e93-ec5828e18655\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(-122.07358%, 0px, 0)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0;border-radius:0.6688963210702341% 0.6688963210702341% 0.6688963210702341% 0.6688963210702341% \/ 0.6211180124223602% 0.6211180124223602% 0.6211180124223602% 0.6211180124223602%\" id=\"el-9abe558d-05d4-485f-aa73-460e680be61a\">\n<h2 class=\"fill text-wrapper\" style=\"white-space:pre-line;overflow-wrap:break-word;word-break:break-word;margin:-0.1410953177257525% 0;font-family:&quot;Roboto&quot;,&quot;Helvetica Neue&quot;,&quot;Helvetica&quot;,sans-serif;font-size:0.485437em;line-height:1.2;text-align:left;padding:0;color:#000000\"><span>We\u2019ve used inexpensive, commercially available reagents to make this compound. The synthesis is very straightforward and you could replicate it yourself<\/span><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"position:absolute;pointer-events:none;left:16.01942%;top:59.2233%;width:66.74757%;height:39.96764%;opacity:1\">\n<div id=\"anim-a13ae289-04c2-4b25-aedd-67d706feced5\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:0;--initial-transform:none\">\n<div id=\"anim-12ff8a68-ba24-48c8-b6f9-4b47dc3e8796\" class=\"animation-wrapper\" style=\"width:100%;height:100%;display:block;position:absolute;top:0;left:0;--initial-opacity:1;--initial-transform:translate3d(0px, 125.19118%, 0)\">\n<div style=\"pointer-events:initial;width:100%;height:100%;display:block;position:absolute;top:0;left:0;z-index:0\" class=\"mask\" id=\"el-46aaf48c-3bd0-4851-ae04-e72062da47ec\">\n<div style=\"position:absolute;width:144.76579%;height:100%;left:-22.3829%;top:0%\" data-leaf-element=\"true\"><amp-img 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style=\"font-weight: 700; color: #fff\">Problem of Functionalizing Pyridines in the Meta-position has been solved<\/span>","borderRadius":{"locked":true,"topLeft":2,"topRight":2,"bottomRight":2,"bottomLeft":2},"x":47,"y":146,"width":316,"height":322,"scale":100,"focalX":50,"focalY":50,"id":"a3dc8a74-b02c-44ee-9210-85efdee78dda","marginOffset":0.8518749999999997}],"backgroundColor":{"color":{"r":255,"g":255,"b":255}},"type":"page","id":"fb9e9e6b-998e-430b-b965-eaf3f3d0c1f8","animations":[],"pageTemplateType":"cover","defaultBackgroundElement":{"opacity":100,"flip":{"vertical":false,"horizontal":false},"rotationAngle":0,"lockAspectRatio":true,"x":1,"y":1,"width":1,"height":1,"mask":{"type":"rectangle"},"isBackground":true,"isDefaultBackground":true,"type":"shape","id":"06176914-a5cb-44c9-a5ee-a84e2350b52b"}},{"elements":[{"opacity":100,"flip":{"vertical":false,"horizontal":false},"rotationAngle":0,"lockAspectRatio":true,"x":1,"y":1,"width":1,"height":1,"mask":{"type":"rectangle"},"isBackground":true,"isDefaultBackground":true,"type":"shape","id":"06176914-a5cb-44c9-a5ee-a84e2350b52b"},{"opacity":100,"flip":{"vertical":false,"horizontal":false},"rotationAngle":0,"lockAspectRatio":true,"backgroundTextMode":"NONE","font":{"family":"Roboto","weights":[100,300,400,500,700,900],"styles":["italic","regular"],"variants":[[0,100],[1,100],[0,300],[1,300],[0,400],[1,400],[0,500],[1,500],[0,700],[1,700],[0,900],[1,900]],"fallbacks":["Helvetica 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