Study reveals new method of preparing imaging agents
Study reveals new method of preparing imaging agents
A new study from Dr. Benjamin Rotstein’s lab at the University of Ottawa has unveiled a new method to prepare isotope-labeled versions of drugs and diagnostics for use in preclinical and clinical research
Study reveals new method of preparing imaging agents
They developed a method to exchange a single atom in amino acids—the building blocks of proteins—to replace it with its heavy isotope, using an elaborate process that requires intense laser light
Study reveals new method of preparing imaging agents
Drug development” means that you need to figure out how much drug to put in a person. In order to do that, you have to study what happens when that drug is put in people
Study reveals new method of preparing imaging agents
Rotstein, an associate professor in the Faculty of Medicine’s Department of Biochemistry, started out with their experiments working like a catalyst
Study reveals new method of preparing imaging agents
They used vitamin B-6 to remove the carboxylic acid from amino acids, and they found it worked like a catalyst
Study reveals new method of preparing imaging agents
he said they were going to run it in reverse, but it turned out that the mechanism was a little different than they initially expected.
Study reveals new method of preparing imaging agents
The research was done in collaboration with university colleagues and chemists at Sanofi, the French pharmaceutical company
Study reveals new method of preparing imaging agents
Dr. Rotstein’s lab did the carbon-11 studies and worked with these collaborators to uncover the mechanism of the reaction
Study reveals new method of preparing imaging agents
Scientists use radioactive carbon-11 to create a map of the brain in a patient’s brain during a PET scan
Study reveals new method of preparing imaging agents
Dr. Rotstein and his team are studying how to make the reaction produce only one “mirror image” version of amino acids so that researchers will no longer need to separate out the mirror images
Study reveals new method of preparing imaging agents
A recent study found that a substance called 11-aminoacids-glucose is a better indicator of diabetes than traditional tests
Study reveals new method of preparing imaging agents
We’re also using these in imaging studies now to learn about metabolism and protein synthesis rates in different tissues,” says Dr
Study reveals new method of preparing imaging agents