Written by Adeel Abbas
Scientists from the Institute of Microbiology of the Chinese Academy of Sciences (IMCAS) recently reported a minimized synthetic carbon fixation cycle. To answer this question, scientists at IMCAS designed a minimized synthetic carbon fixation cycle based on thermodynamic and kinetic calculations of enzymatic reactions.
This synthetic cycle contains only four reactions and the four enzymes involved are pyruvate carboxylase (PYC), oxaloacetate acetylhydrolase (OAH), acetate-CoA ligase (ACS), and pyruvate synthase (PFOR), so this cycle was named the pyruvate carboxylase/oxaloacetate acetylhydrolase/acetate-CoA ligase/pyruvate: ferredoxin oxidoreductase (POAP) cycle.
To construct the POAP cycle, four reactions were divided into two cascades, then the two cascades were assembled together, and the carbon fixation efficiency were tested under anaerobic conditions using 13C-labeled NaHCO3 as the substrate.
More information
Lu Xiao et al, A Minimized Synthetic Carbon Fixation Cycle, ACS Catalysis (2021). DOI: 10.1021/acscatal.1c04151
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